{"id":13868,"date":"2023-02-16T11:11:33","date_gmt":"2023-02-16T04:11:33","guid":{"rendered":"https:\/\/hpsp-prod.th1.proen.cloud\/for-patients\/conditions-we-treat\/pediatric-cancers\/"},"modified":"2023-03-04T21:05:08","modified_gmt":"2023-03-04T14:05:08","slug":"pediatric-cancers","status":"publish","type":"page","link":"https:\/\/hpsp.or.th\/en\/for-patients\/conditions-we-treat\/pediatric-cancers\/","title":{"rendered":"Pediatric cancers"},"content":{"rendered":"<section class=\"wpb-content-wrapper\"><p>[vc_row][vc_column][vc_tta_accordion style=&#8221;modern&#8221; active_section=&#8221;1&#8243; collapsible_all=&#8221;true&#8221; title=&#8221;Proton for Pediatric cancer&#8221;][vc_tta_section title=&#8221;Brain tumors, e.g., Medulloblastoma, Atypical teratoid rhabdoid tumor (ATRT), supratentorial primitive neuroectodermal tumor (S-PNET), Germ cell tumor, Ependymoma, Glioma&#8221; tab_id=&#8221;1677923219300-10f0cba7-424d&#8221;][vc_column_text]<\/p>\n<ul>\n<li>Focal irradiation<\/li>\n<li style=\"list-style-type: none;\">\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li>Total of 25-33 fractions, 1 fraction daily<\/li>\n<li>Potential benefit of proton beam therapy:\n<ul>\n<li>Reduce dose to normal brain parenchyma\n<ul>\n<li>Reduce risk\/severity of cognitive function deterioration, decline of IQ<\/li>\n<li>Reduce risk of second brain tumor<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li>Reduce dose to hearing organ\n<ul>\n<li>Reduce risk\/severity of hearing loss<\/li>\n<\/ul>\n<\/li>\n<li>Reduce dose to pituitary gland, hypothalamus\n<ul>\n<li>Reduce risk\/severity of hormonal deficiency<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<li>Craniospinal irradiation followed by tumor bed boost\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li>Total of 25-33 fractions, 1 fraction daily<\/li>\n<li>Potential benefit of proton beam therapy\n<ul>\n<li>Reduce dose to oral cavity\/pharynx\n<ul>\n<li>Reduce risk\/severity of mucositis, pharyngitis<\/li>\n<\/ul>\n<\/li>\n<li>Reduce dose to thyroid gland\n<ul>\n<li>Reduce risk\/severity of thyroidal deficiency<\/li>\n<\/ul>\n<\/li>\n<li>Reduce dose to heart\n<ul>\n<li>Reduce risk\/severity of heart disease, pericarditis<\/li>\n<\/ul>\n<\/li>\n<li>Reduce dose to lung\n<ul>\n<li>Reduce risk\/severity of pneumonitis, pulmonary fibrosis<\/li>\n<\/ul>\n<\/li>\n<li>Reduce dose to esophagus\n<ul>\n<li>Reduce risk\/severity of esophagitis<\/li>\n<\/ul>\n<\/li>\n<li>Reduce dose to stomach\n<ul>\n<li>\u00a0Reduce risk\/severity nausea\/vomiting<\/li>\n<\/ul>\n<\/li>\n<li>Reduce dose to kidneys\n<ul>\n<li>Reduce risk\/severity of kidney injury<\/li>\n<\/ul>\n<\/li>\n<li>Reduce dose to liver\n<ul>\n<li>Reduce risk\/severity of liver injury<\/li>\n<\/ul>\n<\/li>\n<li>Reduce dose to bowel\n<ul>\n<li>Reduce risk\/severity of abdominal discomfort<\/li>\n<li>Reduce risk\/severity of intestinal fibrosis<\/li>\n<\/ul>\n<\/li>\n<li>Reduce dose to bone marrow\n<ul>\n<li>Reduce risk\/severity of anemia, leukopenia, thrombocytopenia<\/li>\n<\/ul>\n<\/li>\n<li>Reduce dose to nonspecific organs\n<ul>\n<li>Reduce risk of second primary cancer<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>[\/vc_column_text][\/vc_tta_section][vc_tta_section title=&#8221;Extracranial tumor, e.g., rhabdomyosarcoma, Ewing sarcoma, osteosarcoma, neuroblastoma, germ cell tumor&#8221; tab_id=&#8221;1677923396697-a631249c-89cd&#8221;][vc_column_text]<\/p>\n<ul>\n<li>Total of 20-31 fractions, 1 fraction daily<\/li>\n<li style=\"list-style-type: none;\">\n<ul>\n<li>Potential benefit of proton beam therapy\n<ul>\n<li>Depend on the location of tumor<\/li>\n<li>The dose of proton beam that exposes to adjacent organs is probably less than the dose from photon (x-ray) beam e.g.\n<ul>\n<li>Reduce dose to salivary gland\n<ul>\n<li>Reduce risk\/severity of xerostomia<\/li>\n<\/ul>\n<\/li>\n<li>Reduce dose to oral cavity\/pharynx\n<ul>\n<li>Reduce risk\/severity of mucositis, pharyngitis<\/li>\n<\/ul>\n<\/li>\n<li>Reduce dose to thyroid gland\n<ul>\n<li>Reduce risk\/severity of thyroidal deficiency<\/li>\n<\/ul>\n<\/li>\n<li>Reduce dose to heart\n<ul>\n<li>Reduce risk\/severity of heart disease, pericarditis<\/li>\n<\/ul>\n<\/li>\n<li>Reduce dose to lungs\n<ul>\n<li>Reduce risk\/severity of pneumonitis, pulmonary fibrosis<\/li>\n<\/ul>\n<\/li>\n<li>Reduce dose to esophagus\n<ul>\n<li>Reduce risk\/severity of esophagitis<\/li>\n<\/ul>\n<\/li>\n<li>Reduce dose to stomach\n<ul>\n<li>Reduce risk\/severity nausea\/vomiting<\/li>\n<\/ul>\n<\/li>\n<li>Reduce dose to kidneys\n<ul>\n<li>Reduce risk\/severity of kidney injury<\/li>\n<\/ul>\n<\/li>\n<li>Reduce dose to liver\n<ul>\n<li>Reduce risk\/severity of liver injury<\/li>\n<\/ul>\n<\/li>\n<li>Reduce dose to bowel\n<ul>\n<li>Reduce risk\/severity of abdominal discomfort<\/li>\n<li>Reduce risk\/severity of intestinal fibrosis<\/li>\n<\/ul>\n<\/li>\n<li>\u00a0Reduce dose to bone marrow\n<ul>\n<li>Reduce risk\/severity of anemia, leukopenia, thrombocytopenia<\/li>\n<\/ul>\n<\/li>\n<li>\u00a0Reduce dose to skeletal\n<ul>\n<li>Reduce risk\/severity of short stature, limb shortening<\/li>\n<li>Reduce risk\/severity of skeletal fracture<\/li>\n<\/ul>\n<\/li>\n<li>Reduce dose to nonspecific organs\n<ul>\n<li>Reduce risk of second primary cancer<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p>**Note: Patients and their families should discuss and be informed about the potential risk\/benefit of proton and photon beam therapy before making decision. The detail of treatment might be different in each patient.[\/vc_column_text][\/vc_tta_section][\/vc_tta_accordion][\/vc_column][\/vc_row]<\/p>\n<\/section>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column][vc_tta_accordion style=&#8221;modern&#8221; active_section=&#8221;1&#8243; collapsible_all=&#8221;true&#8221; title=&#8221;Proton for Pediatric cancer&#8221;][vc_tta_section title=&#8221;Brain tumors, e.g., Medulloblastoma, Atypical teratoid rhabdoid tumor (ATRT), supratentorial primitive neuroectodermal tumor (S-PNET), Germ cell tumor, Ependymoma, Glioma&#8221; tab_id=&#8221;1677923219300-10f0cba7-424d&#8221;][vc_column_text] Focal irradiation Total of 25-33 fractions, 1 fraction daily Potential benefit of proton beam therapy: Reduce dose to normal brain parenchyma Reduce risk\/severity of cognitive function deterioration,<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":13674,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-13868","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v20.2.1 - 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