{"id":14044,"date":"2023-02-17T01:39:26","date_gmt":"2023-02-16T18:39:26","guid":{"rendered":"https:\/\/hpsp-prod.th1.proen.cloud\/pediatric-brain-tumor\/"},"modified":"2023-02-17T12:09:21","modified_gmt":"2023-02-17T05:09:21","slug":"pediatric-brain-tumor","status":"publish","type":"page","link":"https:\/\/hpsp.or.th\/en\/our-research-and-clinical-trials\/pediatric-brain-tumor\/","title":{"rendered":"Pediatric brain tumor"},"content":{"rendered":"

[vc_row][vc_column][vc_column_text]<\/p>\n

Pediatric brain tumor<\/b><\/h1>\n

Full title:\u00a0 <\/b>Toxicities and survival outcomes of proton beam craniospinal irradiation (P-CSI) for\u00a0\u00a0<\/span>pediatric brain tumor<\/span><\/p>\n

Trial status<\/b>:\u00a0 <\/span>Recruiting<\/span><\/p>\n

First posted<\/b>:\u00a0 <\/span>Feb 14, 2023<\/span><\/p>\n

Last updated:\u00a0 <\/b>Feb 14, 2023<\/span><\/p>\n

Objective:\u00a0 \u00a0 \u00a0 \u00a0<\/b><\/p>\n

Primary objective:<\/span><\/p>\n

    \n
  • \n
      \n
    • To evaluate the rate and severity of neutropenia in pediatric CNS tumor who receive P-CSI<\/span><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

      \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 <\/span>Secondary objective:<\/span><\/p>\n

        \n
      • \n
          \n
        • To evaluate the rates and severities of other acute hematologic toxicities in pediatric CNS tumor who receive P-CSI<\/span><\/li>\n
        • To evaluate the rates and severities of acute non-hematologic toxicities and late toxicities in pediatric CNS tumor who receive P-CSI<\/span><\/li>\n
        • To evaluate the rates of local control, event free survival (EFS), progression free survival (PFS) overall survival (OS) and median survival (MS) in each type of pediatric CNS tumor who receive P-CSI<\/span><\/li>\n
        • To evaluate quality of life of pediatric brain tumor patients who receive P-CSI<\/span><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

          Sample size:\u00a0 <\/b> 60 patients<\/span><\/p>\n

          Inclusion criteria:<\/b> \u00a0<\/b><\/p>\n

            \n
          • Thai children (1-15 year)<\/span><\/li>\n
          • Diagnosed with pediatric brain tumor as follows.
            \n<\/span>Embryonal tumor (Medulloblastoma, PNET, ATRT, Pineoblastoma), Ependymoma with intracranial or spinal metastasis, Pure germ cell tumor with intracranial or spinal metastasis, Non-germinomatous germ cell tumor<\/li>\n
          • ECOG 0-2<\/span><\/li>\n<\/ul>\n

            Exclusion criteria<\/b><\/p>\n

              \n
            • Not receive maximal safe resection prior to radiation for embryonal tumor and ependymoma.<\/span><\/li>\n
            • No MRI spine images<\/span><\/li>\n
            • No CSF cytology report<\/span><\/li>\n
            • Unable to have follow up visits at King Chulalongkorn Memorial hospital<\/span><\/li>\n<\/ul>\n

              Phase:\u00a0 <\/b>2<\/span><\/p>\n

              Disease:\u00a0 <\/b>Pediatric brain tumor<\/span><\/p>\n

              Principle investigator:\u00a0 <\/b>Adjunct Asst. Prof. Chonnipa Nantavithya, M.D.<\/span><\/p>\n

              Co-investigator:<\/b><\/p>\n

                \n
              • Assoc. Prof. Kanjana Shotelersuk, M.D.<\/span><\/li>\n
              • \u00a0<\/b>Anussara Prayongrat, M.D., Ph.D.<\/li>\n
              • Asst. Prof. Kitwadee Saksornchai, M.D.<\/li>\n
              • Thitiporn Jaruthien, M.D.<\/li>\n
              • Asst. Prof. Piti Techavichit, M.D.<\/li>\n<\/ul>\n

                Location:\u00a0 <\/b>King Chulalongkorn Memorial Hospital<\/span>[\/vc_column_text][\/vc_column][\/vc_row]<\/p>\n<\/section>","protected":false},"excerpt":{"rendered":"

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