Our clinical trial: Esophageal cancer
Update on 10 February 2022
Since 2022, we launched the first multi-center randomized trial in Thailand to compare photon therapy or X-ray treatment versus proton therapy in esophageal cancer treatment. Our purpose is to compare two methods of radiation therapy for the treatment of esophageal squamous cell carcinoma (ESCC). The study will compare high-dose intensity-modulated proton therapy (IMPT) with standard-dose intensity-modulated radiation therapy (IMRT). The aim of the trial is to determine if high-dose IMPT is more effective in treating ESCC than standard-dose IMRT. The trial will involve randomly assigning patients with ESCC to either the high-dose IMPT group or the standard-dose IMRT group. The effectiveness of the two treatments will be compared based on factors such as disease control, overall survival, and side effects. The results of this trial will provide important information on the use of IMPT and IMRT in the treatment of ESCC.
The inclusion criteria include:
- Patients with histologically confirmed ESCC
- Age 20-70 years old
- Body weight ≥45 kg
- Good health condition
- Adequate organ function
The exclusion criteria are:
- Distant metastasis
- Evidence of tracheoesophageal or esophagobronchial fistula
- Previous or simultaneous cancer within 2 years, except skin cancer
- History of radiation therapy to the thorax or upper abdomen
- Uncontrolled intercurrent illness
- Pregnancy or lactation
These criteria were established to ensure that patients who are eligible for the study have a similar disease stage and overall health status, and that the results of the trial are as accurate and reliable as possible.
Resource:
Oonsiri S, Kitpanit S, Kannarunimit D, Chakkabat C, Lertbutsayanukul C, Prayongrat A. Comparison of intensity modulated proton therapy beam configurations for treating thoracic esophageal cancer. Phys Imaging Radiat Oncol. 2022 Apr 28;22:51-56.
Lertbutsayanukul C, Kitpanit S, Kannarunimit D, Chakkabat C, Oonsiri S, Thephamongkhol K, Puataweepong P, Katanyoo K, Sukhaboon J, Tovanabut C, Chongsathientham S, Treeratsapanich P, Soonthornrak J, Prayongrat A. High-dose Intensity-modulated proton therapy versus Standard-dose Intensity-modulated RadIation therapy for esophageal squamous cell carcinoma (HI-SIRI): study protocol for a randomized controlled clinical trial. Trials. 2022 Oct 22;23(1):897